Endocrine Abstracts

Background and aims: Multi-drug and toxin extrusion 1 (MATE1) and organic cation transporters 2 (OCT2) are important proteins of metformin transport and excretion in liver and kidney. Our previous study showed that there were gender difference of metformin’s hypoglycaemic effect and it was independently linked with the oestrogen and testosterone levels in type 2 diabetes patients. This study was designed to observe the impact of oestrogen and androgen on the renal express...